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KMID : 0869120100120030127
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기초간호자연과학회지
2010 Volume.12 No. 3 p.127 ~ p.132
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Effect of Xanthium sibiricum Patr. on Carcinogenesis in Human Cell Lines
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So Myung-Suk
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Abstract
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Purpose: The aim of this study is to evaluate the effect of Xanthium sibiricum Patr. on carcinogenesis.
Method: Water extract from Xanthium sibiricum Patr. (XPW) was prepared and investigated for the potential antitumor activity and inhibition of benzo[a]pyrene-DNA adduct formation and free radical formation.
Result: It was shown that the water possess considerable toxicity toward tumor cell lines. Concentration of XPW at 1.0 mg/mL and 2.5 mg/mL resulted in more than 30% inhibition of growth in HeLa cells. Toxicity of XPW to A549 revealed that 54% inhibition of growth at concentration of 2.5 mg/mL. At concentrations of 0.5 mg/mL, 1.0 mg/mL and 2.5 mg/mL of XPW, the binding of []B[a]P metabolites to DNA of human Chang cell was inhibited by 19%, 33%, and 41%, respectively. There 18% and 32% inhibition in the free radical formation with XPW at the concentration of 1.0 mg/mL and 2.5 mg/mL, respectively.
Conclusion: Water extract from Xanthium sibiricum Patr. (XPW) has antitumor and cancer chemopreventive activities.
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KEYWORD
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Xanthium sibiricum Patr., Antitumor activity, Benzo[a]pyrene-DNA formation, Free radical
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